De Chemische Binding

Wiktor Szymanski from the UMCG will give us a lecture about photopharmacology, below you can read the abstract

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Towards theranostic applications of photopharmacology

Wiktor Szymanski, (a,b)

a Medical Imaging Center, University of Groningen, University Medical Center Groningen;
b Stratingh Institute for Chemistry, Faculty of Science and Engineering, University of Groningen

email: w.szymanski@umcg.nls

Light offers unparalled advantages in regulation of compound bioactivity
(photopharmacology, Figure 1A) 1-3 and as an input/output signal in medical
(mostly optical) imaging. 4-5 Combination of those two paradigms along the
principles of theranostics (“treat what you see, see what you treat”) reuires light-
responsive tools that, preferably in combination, enable both therapy and
imaging.

I will present our efforts towards the discovery of such tools, focusing on new (i)
photopharmacological agents, (ii) molecular photoresponsive tools and (iii) new
light-responsive, MRI-active liposomal drug delivery agents (Figure 1B).
References
1. Lerch, M. M.; Hansen, M. J.; van Dam, G. M.; Szymanski, W.; Feringa, B. L. Angew. Chem.,
Int. Ed. 2016, 55, 10978−10999.
2. Broichhagen, J.; Frank, J. A.; Trauner, D. Acc. Chem. Res. 2015, 48, 1947−1960.
3. Hoorens, M.W.H.; Szymanski, W. Trends. Biochem. Sci. 2018, 43, 567-575.
4. Weissleder R.; Ntziachristos V. Nat. Med. 2003, 9, 123-128.
5. Reeßing, F.; Szymanski, W. Curr. Opin. Biotechnol. 2019, 58, 9-18.
Acknowledgements
The financial support of the Dutch Scientific Organisation (NWO VIDI grant 723.014.001 for
WS) is gratefuly acknowleged.

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